-
Top 10
June 2025
Best Flea And Tick Medicine Large Dog
We made a list of the top 10 Flea And Tick Medicine Large Dog based on verified reviews, popularity and other factors which we summarized for you in this list.
Best Choice
1
K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply
K9 Advantix
9.0
VIEW DEAL
Buy on Amazon
✓
K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
✓
Kills fleas within 12 hours of application
✓
Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
✓
Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
✓
No prescription needed
Learn more
on Amazon
More Info
11% Discount
2
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)
PetArmor
8.8
VIEW DEAL
Buy on Amazon
✓
EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
✓
TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
✓
BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
✓
FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
✓
EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months.
Learn more
on Amazon
More Info
11% Discount
3
Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
Frontline
8.7
VIEW DEAL
Buy on Amazon
✓
Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
✓
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
✓
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
✓
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
✓
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
✓
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
✓
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
Learn more
on Amazon
More Info
11% Discount
4
Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments
Frontline
8.6
VIEW DEAL
Buy on Amazon
✓
Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
✓
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
✓
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
✓
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
✓
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
✓
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
Learn more
on Amazon
More Info
5
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary)
K9 Advantix
8.5
VIEW DEAL
Buy on Amazon
✓
K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
✓
Kills fleas within 12 hours of application
✓
Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
✓
Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
✓
No prescription needed
Learn more
on Amazon
More Info
6
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
TevraPet
8.4
VIEW DEAL
Buy on Amazon
✓
COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
✓
ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
✓
STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
✓
EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
✓
MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence
Learn more
on Amazon
More Info
7
PetArmor for Dogs, Flea and Tick Treatment for Large Dogs (45-88 Pounds), Includes 3 Month Supply of Topical Flea Treatments
PetArmor
8.3
VIEW DEAL
Buy on Amazon
✓
DOG FLEA AND TICK CONTROL: PetArmor topical flea and tick treatment kills adult fleas, ticks and chewing lice. Backed by the PetArmor Protection Guarantee.
✓
VET QUALITY FORMULA: Dog flea treatment contains the active ingredient fipronil.
✓
FAST-ACTING FLEA TREATMENT: PetArmor flea treatment for dogs can help you stop an existing flea or tick infestation.
✓
FLEA AND TICK PREVENTION: PetArmor for dogs helps you protect your furry family member from brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may transmit Lyme disease).
✓
INCLUDES: Three (3) topical application tubes for a 3 month supply of dog and flea and tick control. For best results, apply flea & tick treatment for dogs directly to dry skin on your dog's back-between the shoulder blades-on a monthly basis.
Learn more
on Amazon
More Info
8
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses
PetArmor
8.2
VIEW DEAL
Buy on Amazon
✓
FAST-ACTING: One oral flea tablet starts killing fleas within 30 minutes of administration.
✓
SAFE TO USE: This oral flea medication is safe for puppies, dogs, cats, and kittens from 25lbs. and over, when used as directed.
✓
TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas simply apply another dose as often as once a day. CapAction Flea Pills are even safe for use on pregnant or breeding dogs.
✓
EASY TO USE: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription this dog flea tablet is administered orally to kill adult fleas fast.
✓
KILL FLEAS EFFICIENTLY: CapAction flea treatment has 6 doses and kills adult fleas that may cause allergy dermatitis.
Learn more
on Amazon
More Info
6% Discount
9
Amazon Brand - Solimo for Dogs XLarge Dog (89-132 pounds) Flea and Tick Treatment, 6 Doses
Amazon Basics
8.0
VIEW DEAL
Buy on Amazon
✓
Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
✓
One 6 dose pack of Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89 - 132 pounds), 6 Count (Previously Solimo)
✓
Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
✓
Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
✓
One application provides up to 30 days of protection
✓
Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
✓
Packaging received may vary: you may receive product in Solimo or Amazon Basics packaging
✓
Amazon Basics Flea and Tick Topical does not expire
✓
Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385
Learn more
on Amazon
More Info
10
Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)
Amazon Basics
7.9
VIEW DEAL
Buy on Amazon
✓
FAST-ACTING RELIEF: Begin eliminating fleas and ticks within 24 hours of application, providing relief for your large dog
✓
LONG-LASTING PROTECTION: This flea treatment for dogs offers up to 30 days of coverage, protecting your pet from harmful pests
✓
INFESTATION CONTROL: Active ingredients in this dog flea medicine target eggs, larvae, adult fleas, as well as mosquitoes, lice, and flies
✓
FOR LARGE DOGS: Specifically designed for dogs weighing 45-88 pounds, providing a precise and effective flea and tick solution
✓
FORMULA: This topical flea treatment for dogs contains Fipronil and (s)-methoprene
✓
PREVIOUSLY SOLIMO: Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand. Packaging may vary.
Learn more
on Amazon
More Info
How we create our
“
Top 10
“ lists?
Our algorithms collect and evaluate information on millions of products and rank them based on customer reviews, popularity, price and more.
LEARN MORE
Related Reviews
Best
Large Dog Flea And Tick Medicine Pills Oral
View List
Best
Flea And Tick Medicine For Extra Large Dogs
View List
Best
Oral Flea And Tick Medicine For Large Dogs
View List
Best
Chewable Flea And Tick Medicine For Large Dogs
View List
Best
Flea Tick And Worm Medicine For Large Dog
View List
Best
Best Flea And Tick Medicine For Large Dogs
View List
Best
Heart Worm Flea And Tick Medicine For Large Dogs
View List
Best
Frontline Flea And Tick Medicine For Large Dogs
View List
Best
Flea Tick And Heartworm Medicine For Large Dogs
View List
Popular Lists
Headphones
Tablets
Women's Jewelry
Dog Food
Bath Towels
Men's Boxer
Guitars
Robotic Vacuums
Pool Inflatable
TV Streamers
Best Reviews Guide Newsletter
Get exclusive articles, recommendations, shopping tips and sales alerts
SUBSCRIBE