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Top 10June 2025

Best Topical Flea Treatment For Cats Single Dose

We made a list of the top 10 Topical Flea Treatment For Cats Single Dose based on verified reviews, popularity and other factors which we summarized for you in this list.

Best Choice

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

✓Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
✓Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
✓Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
✓Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
✓Fragrance-free formula, waterproof after 24 hours of application

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Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 1-Month Supply

✓Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
✓Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
✓Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
✓Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
✓Fragrance-free formula, waterproof after 24 hours of application

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Cheristin Flea Treatment & Prevention for Cats | Fast acting topical flea treatment for cats over 1.8 lbs | 1 Count

Cheristin Flea Treatment & Prevention for Cats | Fast acting topical flea treatment for cats over 1.8 lbs | 1 Count

✓Cheristin is a fast-acting topical flea treatment for cats
✓Starts to kill fleas in only 30 minutes, kills 98-100% of fleas in 12 hours
✓Convenient one-size-fits-all dose is good for all cats and kittens (1.8 lbs. and greater and 8 weeks of age and older) and a great addition to multi-cat households
✓Easy-to-apply from a small applicator with a rounded tip
✓Long-lasting (through 6-weeks) flea protection your cat deserves

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Flea and Tick Prevention for Cats & Kittens: Waterproof Topical Cat Flea and Tick Treatment – Fast-Acting & Long-Lasting At Home Flea Control for Cats Over 1.5 lbs and 8 Weeks or Older – 6-Dose Supply

Flea and Tick Prevention for Cats & Kittens: Waterproof Topical Cat Flea and Tick Treatment – Fast-Acting & Long-Lasting At Home Flea Control for Cats Over 1.5 lbs and 8 Weeks or Older – 6-Dose Supply

✓Flea & Tick Treatment for Cats: Our cat flea and tick treatment is formulated with vet-approved ingredients to quickly treatment fleas, ticks, larvae, and eggs, providing up to 30 days of continuous protection against
✓Safe & Gentle for All Cats: Designed specifically for cats, our formula is safe for felines weighing over 1.5 lbs, making it suitable for kittens, adult cats, and senior cats. Gentle and non-irritating, it's ideal for cats with sensitive skin.
✓Easy-to-Use: Our topical cat flea treatment is applied directly to the shoulder blades, eliminating the stress of administering oral medications. A simple, mess-free solution for effective flea and tick control.
✓Everyday Protection: Our flea treatment for cats becomes waterproof 24-48 hours after application, allowing your cat to bathe and play as usual without compromising effectiveness—protection that lasts an entire month.
✓Prevents Reinfestation: Not only does it eliminate existing fleas and ticks, but it also prevents new infestations by disrupting the parasite life cycle. A complete flea and tick prevention for cats solution for long-term health and comfort.

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Advantage XD Large Cat Flea Prevention & Treatment For Cats over 9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose

Advantage XD Large Cat Flea Prevention & Treatment For Cats over 9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose

✓2 months (1 dose) flea treatment and prevention for indoor and outdoor cats or kittens over 9 lbs., 8 weeks or older
✓Longer-lasting protection vs. other topical products; 2 months protection per dose, outlasting the typical flea life cycle
✓Fast-acting treatment starts killing fleas through contact within 30 minutes to 4 hours
✓Easy-to-apply topical treatment, no prescription needed
✓Fragrance-free formula, containing a naturally derived ingredient Spinetoram - winner of a Green Chemistry award US EPA Presidential Green Chemistry Challenge. Designing Greener Chemicals Award. 2008.

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Advantage XD Small Cat Flea Prevention & Treatment For Cats 1.8-9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose

Advantage XD Small Cat Flea Prevention & Treatment For Cats 1.8-9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose

✓2 months (1 dose) flea treatment and prevention for indoor and outdoor cats or kittens 1.8-9 lbs., 8 weeks or older
✓Longer-lasting protection vs. other topical products; 2 months protection per dose, outlasting the typical flea life cycle
✓Fast-acting treatment starts killing fleas through contact within 30 minutes to 4 hours
✓Easy-to-apply topical treatment, no prescription needed
✓Fragrance-free formula, containing a naturally derived ingredient Spinetoram - winner of a Green Chemistry award US EPA Presidential Green Chemistry Challenge. Designing Greener Chemicals Award. 2008.

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28% Discount

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

✓EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
✓TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
✓BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle Kill flea eggs and larvae to prevent re-infestation.
✓FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
✓EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with three (3) waterproof topical applications that provides your pet flea protection and control for three (3) months.

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PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 1 Dose, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 1 Dose, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

✓Effective, Waterproof Flea Treatment for Cats: PetArmor plus topical flea and tick Prevention for cats kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application
✓Trusted, Vet Quality* Formula: this vet-quality formula flea treatment contains fipronil and begins killing fleas & ticks within 24 hours
✓Break the Flea Cycle: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation
✓Fast-Acting Long-Lasting Flea and tick Protection: PetArmor plus for cats helps you protect your furry family member from the diseases fleas and ticks carry, including deer ticks that may transmit Lyme disease
✓Easy-to-Use, Long-Lasting: PetArmor Plus flea and tick treatment comes with one (1) waterproof topical application that provide your pet flea protection and control for one (1) months

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17% Discount

Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments

Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments

✓Topical drop formula kills fleas and deer ticks
✓Includes 3 monthly treatments in easy to apply, single dose tubes
✓Repels mosquitoes for 18 days
✓For use on cats and kittens 12 weeks and older weighing 5 pounds and over

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11% Discount

Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 3 Count (Previously Solimo)

Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 3 Count (Previously Solimo)

✓Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
✓Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
✓Active ingredients prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
✓One application provides up to 30 days of protection
✓Waterproof: 24 hours after application your pet's treatment is protected against rain and water activities
✓Packaging received may vary: you may receive product in Solimo or Amazon Basics packaging
✓Amazon Basics Flea and Tick Topical does not expire

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