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Top 10July 2025

Best Oral Dog Flea And Tick Treatment Pills For Large Dogs

We made a list of the top 10 Oral Dog Flea And Tick Treatment Pills For Large Dogs based on verified reviews, popularity and other factors which we summarized for you in this list.

Best Choice

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply

K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply

✓K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
✓Kills fleas within 12 hours of application
✓Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
✓Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
✓No prescription needed

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11% Discount

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)

✓EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
✓TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours.
✓BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
✓FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six months.
✓EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months.

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TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment

✓COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
✓ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
✓STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
✓EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
✓MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence

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PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses

✓FAST-ACTING: One oral flea tablet starts killing fleas within 30 minutes of administration.
✓SAFE TO USE: This oral flea medication is safe for puppies, dogs, cats, and kittens from 25lbs. and over, when used as directed.
✓TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas simply apply another dose as often as once a day. CapAction Flea Pills are even safe for use on pregnant or breeding dogs.
✓EASY TO USE: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription this dog flea tablet is administered orally to kill adult fleas fast.
✓KILL FLEAS EFFICIENTLY: CapAction flea treatment has 6 doses and kills adult fleas that may cause allergy dermatitis.

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CAPSTAR Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Medium & Large Dogs (Over 25 lbs), 6 Doses

CAPSTAR Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Medium & Large Dogs (Over 25 lbs), 6 Doses

✓Fast-Acting Flea Treatment: Capstar (nitenpyram) starts eliminating adult fleas in just 30 minutes
✓Tackle Flea Infestations Fast: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
✓Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose as often as once a day
✓No Prescription Needed: Fast, effective flea treatment that's available over the counter
✓Intended Use: Capstar Oral Flea Treatment for Large Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 25.1-125 pounds

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Advantus Dog Fast Acting Oral Flea Treatment Soft Chews Dogs 23 - 110 lbs. | 7 ct.

Advantus Dog Fast Acting Oral Flea Treatment Soft Chews Dogs 23 - 110 lbs. | 7 ct.

✓Advantus (imidacloprid) is a flavored soft chew that, with one dose, starts killing adult fleas within one hour so your dog can get back to enjoying life
✓This chewable flea treatment is available without a prescription
✓Treats flea infestations on dogs and puppies 10 weeks of age and older and weighing from 23 - 110 lbs.
✓Easy-to-give soft chew that can be administered to your dog as often as once daily if they become re-infested
✓Advantus is also available for dogs ranging in weight between 4 and 22 lbs.

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Amazon Brand - Solimo for Dogs XLarge Dog (89-132 pounds) Flea and Tick Treatment, 6 Doses

✓Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
✓One 6 dose pack of Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89 - 132 pounds), 6 Count (Previously Solimo)
✓Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
✓Active ingredients Fipronil and (s)-methoprene prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
✓One application provides up to 30 days of protection
✓Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
✓Packaging received may vary: you may receive product in Solimo or Amazon Basics packaging
✓Amazon Basics Flea and Tick Topical does not expire
✓Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385

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22% Discount

Flea and Tick Prevention for Dogs Chewables -Made in USA- Natural Dog Flea and Tick Treatment - Oral Flea Pills - Vet Recommended Flea and Tick Chews - All Breeds & Sizes - 120 Soft Treats (Chicken)

Flea and Tick Prevention for Dogs Chewables -Made in USA- Natural Dog Flea and Tick Treatment - Oral Flea Pills - Vet Recommended Flea and Tick Chews - All Breeds & Sizes - 120 Soft Treats (Chicken)

✓Flea And Tick Prevention For Dogs: Natural essentials your dog needs in a perfectly balanced formula to boost skin, coat & immune health and prevent fleas & ticks from laying eggs on your dog’s coat.
✓Dog Flea And Tick Treatment with Skin & Coat Support : Flax seed + Neem + Coriander for dogs naturally repels flea & tick when used daily. Vet Treat Flea and Tick chews provide additional benefits to your dog's skin & coat health with Vitamin B Blend.
✓No Garlic, No Chemicals: All natural and science-backed ingredients. Natural alternative to synthetic pesticides. Dog skin & coat supplement for flea and tick prevention.
✓Vet Recommended + Made In U.S.A + Clinically Tested: Made in the U.S.A in an FDA-registered facility by veterinarians and animal nutritionists. Clinically tested for safety by a third-party laboratory in the US.
✓Flea & Tick Control For All: Tasty chicken-flavored dog flea and tick repellent chews are safe and effective for all ages, sizes & breeds. We left no dog behind.

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Flea and Tick Prevention for Dogs Chewables - 170 Treats - Natural Dog Flea and Tick Treatment Chewable Supplement - Oral Pills - All Breeds & Ages - Soft Chews - Made in USA - Bacon Flavor

Flea and Tick Prevention for Dogs Chewables - 170 Treats - Natural Dog Flea and Tick Treatment Chewable Supplement - Oral Pills - All Breeds & Ages - Soft Chews - Made in USA - Bacon Flavor

✓Natural Flea & Tick Prevention: Defend your dogs from pests the natural way with our flea prevention for dogs - a safer alternative for itch-free protection
✓Optimal Protection: To achieve the best outcomes, administer our chewable flea and tick prevention tablets to your dog on a daily basis. This helps establish the necessary levels in their system for effective protection.
✓Suitable for All Breeds and Ages: Whether you’re caring for a teacup pup or a gentle giant, our flea chews for dogs are designed to keep dogs of all breeds and ages happily protected
✓Veterinarian Formulated & USA Made: Trust in the premium quality of our dog flea & tick control chews, which are formulated by veterinarians and manufactured in the USA within an FDA-registered facility
✓Hassle-Free Administering: Forget the struggle of topical treatments - our tasty chicken-flavored chewables make administering flea and tick prevention a treat, not a chore

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Flea and Tick Prevention for Dogs Pills - Natural Dog Flea & Tick Control - 170 Soft Chewables - Oral Defense Treatment for Dogs Supplement - Vet Formulated Chews - All Breeds & Ages - Made in USA

Flea and Tick Prevention for Dogs Pills - Natural Dog Flea & Tick Control - 170 Soft Chewables - Oral Defense Treatment for Dogs Supplement - Vet Formulated Chews - All Breeds & Ages - Made in USA

✓Effective Flea & Tick Protection: These flea pills for dogs provide lasting defense against pests, protecting your dog from infestations and discomfort while keeping them healthy and itch-free.
✓Easy & Tasty Chewable Formula: Our dog flea and tick treatment chewable is a hassle-free alternative to sprays and collars, providing essential protection in a delicious chew dogs love.
✓Natural & Safe Ingredients: Manufactured with carefully selected natural ingredients, our flea and tick prevention for dogs chewable helps protect your dog's health without harsh chemicals.
✓Vet-Recommended for All Breeds & Sizes: This dog tick and flea treatment provides reliable protection for small, medium, and large dogs, ensuring year-round defense for all breeds, sizes, and ages.
✓Made in the USA in an FDA-Registered Facility: Our best flea and tick chews for dogs are made under strict quality control standards to ensure safety, purity, effectiveness for dependable protection.

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