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Top 9August 2025

Best Cystic Acne Spot Treatment Cream

We made a list of the top 9 Cystic Acne Spot Treatment Cream based on verified reviews, popularity and other factors which we summarized for you in this list.

Best Choice

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Remover for Face, Back and Body - with 10% Azelaic Acid - Teens 13-19 & Young Adult 20-30, 1.8 oz

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Remover for Face, Back and Body - with 10% Azelaic Acid - Teens 13-19 & Young Adult 20-30, 1.8 oz

Enaskin Naturals

✓Anti-Acne Powerhouse：Clinically proven with 10% Azelaic Acid + 2% Salicylic Acid to reduce cystic acne swelling by 73%* overnight while unclogging pores. Dermatologist-tested for stubborn hormonal breakouts in teens & adults (13-30), this deep-penetrating formula targets acne on face, back, chest, and body without over-drying skin layers.
✓Scar-Fading Complex: Non-comedogenic Niacinamide & Tea Tree Oil visibly fade post-acne marks in 14 days* while calming redness. The environmental-shield formula protects sensitive skin during school/sports/commuting, preventing new breakouts in classrooms, gyms, and workplaces.
✓Rduce Cystic pimples: Relief active cystic pimples while gradually releasing tea tree antioxidants over 8 hours. 72% of users report reduced midday shine* through sebum-control matrix that targets root causes of teen/adult acne.
✓Fast-Absorbing Defense: Ultra-lightweight gel-cream absorbs in 20 seconds (89% trial-proven*) without pilling under makeup/SPF. pH-balanced (5.2-5.8) for daily use on face, bacne areas, and mask-prone zones, maintaining moisture during workouts/humidity.
✓Hygienic Protection System: To maintain ingredient potency & prevent contamination. Cruelty-free & compliant, this travel-friendly 1.8oz bottle for consistent treatment from dorm rooms to business trips.

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36% Discount

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

✓Severe Acne Spot Treatment: Maximum strength, 10% Benzoyl Peroxide fights severe acne and prevents new acne from forming. Dermatologist developed and tested; Oil free and fragrance free
✓Reduces Redness and Soothes: Ginger is an effective treatment for acne, fighting active blemishes and treating skin until cleansing while Chamomile soothes
✓Healthy Skin Solutions: We carry a full line of treatment kits, cleansers, moisturizers, detox masks, scrubs, creams, toners and other targeted solutions for sensitive, oily and acne prone skin
✓Dermatology Inspired Care: Our products offer hydration, soothing, detoxifying and mattifying benefits to help ensure your skin looks and feels healthy and help maintain your skin’s balance with consistent use
✓Dermatologist Recommended: Built on a foundation of dermatological science and research, doctors consistently recommend our products to men, women, teens and adults in need of gentle yet effective acne treatment

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Cystic Acne Spot Treatment Cream for Face, Back, Butt, Body - Spot Treatment for Pimples, Blemishes, Blackheads, Oil Control - Natural Ingredients - for Teens, Women, and Men

Cystic Acne Spot Treatment Cream for Face, Back, Butt, Body - Spot Treatment for Pimples, Blemishes, Blackheads, Oil Control - Natural Ingredients - for Teens, Women, and Men

✓Advanced Cystic Acne Treatment: This acne cream targets cystic acne, whiteheads, and blackheads while being gentle and moisturizing. Designed for all acne-prone skin types, it helps reduce oil production to prevent scarring and future breakouts.
✓Say Goodbye to Blemishes: Our fast-acting formula is designed to improve the look of acne-prone skin. Powered by Salicylic Acid, it gently exfoliates, unclogs pores, and smooths skin texture while promoting clarity.
✓Gentle and Natural Formula: Crafted with Salicylic Acid, Tea Tree Oil, Centella Asiatica Extract, Salvia Miltiorrhiza Extract, and White Willow Bark Extract, this acne cream soothes, hydrates, and supports balanced skin. Allergy-tested and free of harsh ingredients, it’s ideal for everyday use.
✓Safe and Effective for All Skin Types: Formulated for dry, sensitive, and oily skin, it’s gentle enough for daily use without irritation. Free of harsh additives, it’s an effective skincare option for both men and women.
✓How to Use: Apply a small amount to areas of concern on the face or body, such as the back, chest, neck, shoulders, or upper arms. Use once or twice daily; for persistent issues, apply up to three times daily. For best results, continue use for at least four weeks.

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34% Discount

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Breakouts for Face, Back and Body - 10% Azelaic Acid & Salicylic Acid - Teens-Adults, 1.8 oz

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Breakouts for Face, Back and Body - 10% Azelaic Acid & Salicylic Acid - Teens-Adults, 1.8 oz

Enaskin Naturals

✓SAY BYE-BYE TO ACNE BREAKOUTS: Fast-clearing solution for stubborn acne spots. Maximum strength 10% Azelaic Acid penetrates deep into cystic pimples to reduce inflammation and prevent new hormonal acne within 4 weeks.
✓VARIOUS BENEFITS FOR ACNE-PRONE SKIN: This hormonal acne treatment cream effectively tackles cystic, hormonal, and severe acne. Targets multiple skin concerns including body/back acne, redness, whiteheads, excess oil, and enlarged pores.
✓NATURAL AND GENTLE FORMULA: Contains salicylic acid, tea tree oil, niacinamide and natural active ingredients. Unclogs pores on face, back and body while fading post-acne dark spots. Combats stress-induced jawline/chin breakouts without disrupting the skin's moisture barrier.
✓IMPROVED PACKAGING: Features an easy-push pump bottle with large capacity for long-term use. Airtight design preserves cream freshness. Fast-absorbing texture treats back and chest breakouts discreetly under professional attire, with tea tree oil controlling odor-causing bacteria.
✓HOW TO USE: After cleansing/toning, apply generously to affected areas and rinse off next morning. Avoid large-area application and eye contours. Use 1-2 times daily (2-3 times for severe acne) for a minimum of 4 weeks.

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De La Cruz Sulfur Ointment - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask - Safe and Effective Game Changing Hormonal Acne Treatment that Clears Up Pimples - 2.6 OZ Tube

De La Cruz Sulfur Ointment - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask - Safe and Effective Game Changing Hormonal Acne Treatment that Clears Up Pimples - 2.6 OZ Tube

✓GOOD BYE BLEMISHES See overall skin improvement in just a few days. De La Cruz Sulfur Ointment is designed to leave your skin feeling smooth, less oily and blemish free.
✓STOP PIMPLES IN THEIR TRACKS Our maximum strength cystic acne treatment penetrates the pores, eliminating pimples and blackheads and helps prevent any new pimples and blackheads from forming.
✓CLEARS ACNE ON THE SPOT Whether you have hormonal acne or cystic acne, blackheads or even acne scars, our 10% sulfur ointment is an ideal acne treatment for face and body.
✓10 MINUTE SULFUR ACNE TREATMENT Apply a thin layer over your face, back or any affected area, wait 10 minutes and wash off with warm water. Apply daily for best results.
✓SAFE TO USE De La Cruz’s acne cream is allergy tested, with no artificial fragrances, colors or parabens and won’t clog pores. Made in the USA and never tested on animals (we love them).

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8% Discount

De La Cruz 10% Sulfur Ointment Travel Size - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask Safe and Effective Game Changing Hormonal Acne Treatment 0.21oz 6g

De La Cruz 10% Sulfur Ointment Travel Size - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask Safe and Effective Game Changing Hormonal Acne Treatment 0.21oz 6g

✓GOOD BYE BLEMISHES You will notice acne and overall skin improvement within just a few days! This fast action sulfur cream will leave your skin feeling smooth, less oily and blemish free!
✓STOP PIMPLES IN THEIR TRACKS Maximum strength cystic acne treatment penetrates the pores eliminating pimples and blackheads. It helps prevent any new pimple and blackhead from forming.
✓CLEARS ACNE ON THE SPOT Whether you have hormonal or severe cystic acne, blackheads or even acne scars, DLC's Sulfur Ointment is the best treatment for acne prone skin.
✓10 MINUTE ACNE TREATMENT Apply a thin layer over your face, back or the affected area, wait 10 minutes and wash off with warm water. A consistent daily regimen will ensure the best results.
✓NEVER TESTED ON ANIMALS This effective acne ointment has been allergy tested and does not contain fragrance, parabens or artificial colors. It is non-comedogenic (does not clog pores). Made in USA.

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TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

✓Effectively Combats Cystic Acne: Our nature-powered cystic acne treatment uses Bentonite Clay, Sulfur, and Tea Tree Oil to effectively pull out and dry out stubborn cystic acne. It can also be used as an acne on buttocks treatment for women and men.
✓Acne Spot Treatment for Face: With over 120 uses per 0.5oz container, this is a long-lasting solution for cystic acne treatment for the face and body, and for adult cystic acne treatment for women and men. It rids acne, whiteheads, and blackheads.
✓Clears Cystic Acne On The Spot: Fast and noticeable results in just 20 minutes, this cystic acne overnight treatment is perfect for cystic acne treatment for sensitive skin and as a pimple cream spot treatment overnight use for face and body.
✓Works For All Skin Types: Designed for sensitive skin, this cystic acne spot treatment for adults includes Aloe to soothe sensitive skin. This is vegan, cruelty-free, and free of parabens, making it a perfect spot treatment for cystic pimples.
✓Try Our Acne Skin Care Regimen: 5 Step Acne Treatment Kit - Acne Face Wash, Acne Face Cream, Salicylic Acid Acne Toner, Acne Face Scrub, and Acne patches. Also, try our salicylic acid spot treatment and acne scar treatment for face consistently.

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Cystic Acne Spot Treatment – Tea Tree Acne Cream – Fast-Acting Acne Spot Corrector for Face, Pimples & Blemishes – Non-Greasy, Gentle Formula – 1oz – by WELLUTION

Cystic Acne Spot Treatment – Tea Tree Acne Cream – Fast-Acting Acne Spot Corrector for Face, Pimples & Blemishes – Non-Greasy, Gentle Formula – 1oz – by WELLUTION

✓CLINICALLY EFFECTIVE HERBAL FORMULA: Formulated with Tea Tree Oil, Bentonite Clay, and Organic Arnica, this natural spot cream helps reduce the appearance of deep, cystic acne while supporting skin clarity. Aloe Vera and Vitamin E calm and nourish without harsh chemicals.
✓GENTLE YET POWERFUL – WORKS FAST: Fast and noticeable results in just 20 minutes, this cystic acne overnight treatment is perfect for cystic acne treatment for sensitive skin and as a pimple cream spot treatment overnight use for face and body.
✓ESTIMATED 2–4 WEEKS SUPPLY: Each 1oz tin provides enough product for up to a month of daily use when applied 1–2 times per day. A little goes a long way—smooth it onto spots, not your whole face.
✓NON-GREASY WITH INVIGORATING SCENT: Goes on clean and dries fast, with a light, natural lemon-rosemary scent. No artificial fragrances or synthetic perfumes—just botanical calm.
✓MADE IN USA WITH PURE INGREDIENTS: Produced in a GMP-certified facility using only natural, non-GMO ingredients. No parabens, dyes, or animal testing. Safe for all skin types, including sensitive or mature skin.

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Ayadara Cystic Acne Spot Treatment, Overnight Hormonal Cystic Acne Treatment for Face, Women, Men and Teens, Cystic Hormonal Acne Treatment for Body, Pimple Cream, Sulfur Acne Spot Treatment, 120 Uses

Ayadara Cystic Acne Spot Treatment, Overnight Hormonal Cystic Acne Treatment for Face, Women, Men and Teens, Cystic Hormonal Acne Treatment for Body, Pimple Cream, Sulfur Acne Spot Treatment, 120 Uses

✓Clears Cystic Acne On The Spot: It's time to address cystic acne overnight. This hormonal acne cream delivers fast and evident improvements in your skin's condition. Use our cystic pimple spot treatment overnight for your face, chest, back, or body.
✓Nature-Powered Ingredients: Zap away stubborn acne with our powerful acne treatment. Our lightweight cystic acne spot cream has ingredients such as sulfur, witch hazel, lemon oil and bentonite clay to help banish pimples.
✓A Little Goes A Long Way: Featuring over 120 uses, this cystic acne overnight treatment can be used anywhere on your body or face. Formulated to work on all types of acne, this severe acne treatment for face lessens the appearance of hormonal acne.
✓For All Skin Types: Clear skin doesn't get any simpler than this adult acne spot treatment. Formulated with Aloe to soothe sensitive skin, this cystic acne treatment cream is vegan, cruelty-and-paraben-free. So, it's gentle enough to use daily.
✓How To Use: Apply a tiny amount of Warrior Two onto your cystic hormonal acne. Give it time to absorb into the skin. Wait for 30 minutes before rinsing or leave it overnight for extra strength. Pair it with our Ayadara Charcoal to Sparkle Face Wash.

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